Interleukin-6 production by human monocytes stimulated with Cryptococcus neoformans components.
نویسندگان
چکیده
In order to ascertain if Cryptococcus neoformans components can induce interleukin-6 (IL-6) production, we stimulated human whole blood with purified capsular products. Their potencies in stimulating IL-6 release were mannoproteins > galactoxylomannan = glucuronoxylomannan > alpha(1-3)glucan. IL-6 production was tumor necrosis factor alpha independent and required the presence of monocytes and plasma. Since IL-6 can stimulate replication of the human immunodeficiency virus in monocytic cells, these findings may be clinically relevant.
منابع مشابه
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ورودعنوان ژورنال:
- Infection and immunity
دوره 65 6 شماره
صفحات -
تاریخ انتشار 1997